Stanozolol is the second most popular anabolic-androgenic steroid (AAS) in the world after methadienone. Locally, it is known as Winstrol, Strombafort or “wine”. The compound name is 17beta-Hydroxy-1 7-methyl-Salphaandrostano [3,2-c] pyrazole. It is one of the oldest steroid drugs, as its mass production began in 1962, 4 years after its synthesis. This event took place in Great Britain, and the drug was signed with the now legendary name of Winstrol. To this day, it is used both in human and animal therapies. Over the years, it has been used to treat coagulation disorders, anemia, loss of bone and muscle mass, as well as vascular edema. However, this compound has been superseded by more specific drugs with fewer side effects.
Stanozolol is a derivative of testosterone, specifically its much more metabolically active metabolite, dihydrotestosterone (DHT). Several changes have been made to the structure of this hormone; namely adding a methyl group to the compound at the 17th position (methylation) and placing a pyrazole ring in place of the 3-keto group.
The agent is extremely universal, which makes it popular in many sports, from American football, through martial arts, to body and strength sports.
Good for cutting and power.
Stanozolol’s main mechanism of action is its ability to dock to the androgen receptor, which is found in most tissues throughout the body. It has also been proven that the agent is also able to dock to the corticosteroid receptor, progesterone and, which is very important in bodybuilding, estrogens. The compound, after removing the methyl group in the liver, becomes biologically active, while requiring high enzymatic activity from it.
Stanozolol has a very low affinity for steroid hormone binding globulins. It is not a substrate for the aromatase enzyme or 5-alpha-reductase, so it does not directly affect the level of estrogens and dihydrotestosterone, but as a derivative of this hormone, it can slightly lower the levels of progesterone.
Due to the wide dispersion of the androgen receptor, but also other receptors to which stanozolol has an affinity, the agent in its active form affects the skin, joints, bones, muscles and the nervous system.
EFFECTS OF OPERATION
Its popularity as a doping agent did not come out of nowhere; it has a wide range of properties useful in most sports.
SIGNIFICANT IMPROVEMENT OF EFFICIENCY
The reason why athletes reach for such a broad spectrum of stanozolol is its rapid increase in the ability to generate strength without gaining weight. This effect is the result of the compound’s activity within the muscle tissue and on the cells of the nervous system. Stanozolol allows for significantly more efficient work of these tissues, while significantly accelerating their regeneration after the stress factor of heavy training.
DECREASE OF ESTROGEN ACTIVITY
DHT, to put it very simply, is considered to be a specific estrogen antagonist. These hormones do not directly affect their level, but DHT is able to reduce the activity of estrogen in tissues. This fact results from the ability to dock androgen to the estrogen receptor, showing a stronger affinity for it than the estrogens themselves. What does this mean in practice? Stanozolol, being a DHT derivative, is able to reduce the effect of estrogens without affecting their amount. Therefore, it reduces the estrogen-induced water retention, which also improves the quality of the figure, giving it a dry, raw appearance.
SUPPORT FOR JOINT REGENERATION
Interesting and somewhat surprising for some may be the positive effect of stanozolol on connective and bone tissue. It turns out that stanozolol is able to increase collagen synthesis as well as promote the formation of new osteocytes. In therapeutic doses, this agent may contribute to accelerated convalescence after injuries of the locomotor system. [3,12,16-19]
The agent, showing affinity for glucocorticosteroid receptors, as well as activation of the androgen receptor, stanozolol is able to reduce catabolic reactions taking place in the body. It reduces the breakdown of proteins by reducing the action of cortisol, partially by taking over its receptors. Thus, the agent may limit the breakdown of muscle tissue in the conditions of increased stressors, e.g. energy deficit, increased training frequency or broadly understood stress. [1,2,3,5]
LOWERING THE SHBG LEVEL
Ultimately, it enhances the potential of other SAA compounds by exceptionally effective in reducing Sex Hormone Binding Globulin (SHBG). These globulins catch the free form circulating hormones in the bloodstream, temporarily depriving them of the possibility of docking to receptors and thus exerting an influence on the body. Stanozolol, an androgen, is able to effectively lower SHBG, which results in an increased amount of free (not globulin bound) steroid hormones. Thus, it can enhance the effect of e.g. testosterone. The oral version of stanozolol is considered to be particularly effective in this context, but the injectable version also has this effect.
POSSIBLE SIDE EFFECTS
In most cases of AAS, the more benefits the relationship brings, the greater the side effects it can cause. It is no different in the case of stanozolol.
The use of stanozolol, regardless of the duration of the cycle, is always associated with disturbances in the body’s lipid metabolism. This is mainly due to its androgenic nature, but also to accumulation in the liver during the first pass, when the organ separates the methyl group from the compound. As a result, the compound in a short time significantly reduces the level of HDL fraction lipoproteins, while increasing the concentration of the LDL fraction and total cholesterol. [4,7,9,10,13,14]
DISORDERS OF THE CARDIOVASCULAR SYSTEM
Stanozolol may lead to the intensification of hematopoietic processes, causing hyperemia, i.e. overproduction of hemoglobin and red blood cells. The long-term aftermath of both hyperemia and the abnormalities in the lipidogram described above is the development of numerous cardiovascular diseases such as hypertension, atherosclerosis, and ischemic heart disease. Therefore, the measure, without appropriate prophylaxis, may contribute to the occurrence of stroke, infarction or other vascular incidents. In addition, stanozolol, like any anabolic androgenic steroid, may increase the effect of left ventricular hypertrophy in people who practice sports for many years. 
Stanozolol, being an agent with considerable androgenic potential, also causes side effects characteristic of this type of agents. Due to the sensitivity of androgen receptors, women will be a special risk group. Symptoms of virilization can be observed even at low doses of stanozolol; new body hair, lowering the tone of the voice or oily skin and acne. Long-term abuse of stanozolol may result in clitoral growth and changes in facial features to male ones.
On the other hand, among men, the list of side effects includes hair loss, oily skin, acne and increased aggressiveness. In the long term, it may increase prostate enlargement.
Importantly, this effect is not due to the activity of 5-alpha-reductase, but the structure of the agent. Thus, counteracting these side effects is practically impossible.
As a methylated agent, stanozolol is a heavy burden on the digestive system, especially the liver and bile ducts. The liver is responsible for the separation of the methyl group from the compound, thanks to which the highest concentration of the substance is found in this organ. This fact is also confirmed by the biochemical parameters during the application; standard is significantly elevated levels of ALT, ASP, bilirubin, lipase and GGTP. Accumulation of the agent in the liver causes serious damage to the organ. There is also nausea, diarrhea and vomiting. [4,7,9,10,13]
HORMONAL HOMEOSTASIS DISORDERS
Taking stanozolol causes hormonal disorders, leading sooner or later to the blockage of testosterone secretion. The result may be erectile dysfunction, mood swings, decreased libido, decreased concentration and a significant reduction in the level of physical efficiency. This effect may resolve spontaneously over time, however, appropriate therapy is strongly recommended. [1-4,11,20]
Due to its strong affinity to the estrogen receptor, the agent limits the activity of estrogens also within the joint tissues. Estrogens, being an extremely important element in the synthesis of collagen, but also a ligand activating numerous mechanisms in the bone tissue, ensure the proper functioning of the joints. Stanozolol, winning the competition for the estrogen receptor, disrupts the proper functioning of the hormone, which may cause joint pain.
WITH WHAT TO COMBINE?
Stanozolol, due to the wide spectrum of offered activities, fits well in many cycle scenarios.
In the case of building dry muscle mass, it is a good combination with testosterone, boldenone, nandrolones, YK-11, GHRP and GHRH peptides and insulin.
When building strength, it is most often combined with testosterone, nandrolone and mk-677. Advanced competitors combine stanozolol with oxymetholone just before the starts.
During reduction, stanozolol is most often combined with trenbolone, ephedrine, yohimbine, GW-501516, SR-9009, rHGH fragment 176-191, with a small testosterone base.
The effectiveness of the measure, regardless of the form, is considered to be similar; that is, similar stanozolol analogues are used for the oral and injection versions. Most of the scientific research is based on the administration of this compound in the oral form, which has a shorter half-life, which also works more aggressively.
In the case of oral stanozolol, it is optimal to use 3 doses a day, approximately every 8 hours.
The injection version should be used at least every other day, ideally every day.
For therapeutic purposes, oral stanozolol was used in doses of 4-6 mg per day, broken down into 2-3 equal doses. In order to improve physical performance and aesthetics of the figure, this dosage may work for women who are still advised to avoid this measure.
In the case of men, standard doses range from 15 to even 100 mg, depending on the purpose and duration of use.
During the period of building strength or muscle mass, the agent is usually taken in doses of 15-50 mg of stanozolol daily.
During weight loss / preparations for bodybuilding competitions, doses of 30-100 mg of stanozolol per day are used.
In order to support the regeneration of joint tissues, a maximum dose of 10 mg is considered a sufficient dose.
This measure should not be used for too long without breaks; it is considered that the risk of side effects from the liver or lipids does not reach a drastic scale after taking the drug for up to 8 weeks. Regardless of the dose level and the period of use, it makes best sense to perform biochemical tests to monitor the health of the organs.
The agent, being 17-alpha-alkylated, remains hepatoxic, therefore it is recommended to use it for the shortest possible time; usually up to 8 weeks. During this time, you should take care of liver prophylaxis, so it will be a good idea to take N-Acetyl-L-Cysteine, Choline Bitartrate, increase water supply. When using high doses or prolonged cycles, it is worth considering taking stronger agents, such as Heparegen or supplementing with TUDCA or Liv52 supplementation.
This measure strongly disturbs the lipid metabolism; Research indicates that a dose of 6 mg used for a longer period causes drastic, unfavorable changes in the level of HDL and LDL lipoproteins. Therefore, it is suggested to limit the supply of saturated fat and increase the supply of polyunsaturated fatty acids. In addition, as an element of prophylaxis, GW-501516 will be particularly good, supplementation with a large amount of omega-3, Citrus Bergamotti extract may also be helpful.
Stanozolol is perfectly compatible with most SAA and SARM compounds, but due to the above-mentioned hepatoxicity, care should be taken when using other oral or alkylated compounds in parallel. There are many reports of medical cases in which bodybuilders developed severe liver dysfunction as a result of long-term use of stanozolol with methadienone (popular Metanabol / Dianabol) and other hepatoxic agents. It is worth adding here that the use of stanozolol in the injection version does not reduce the risk of overload and, as a result, liver damage.
The center, as representative of the SAA, blocks the HPTA axis. Therefore, after its use, a full-scale PCT (Post Cycle Therapy) protocol should be carried out, i.e. unblock Such a therapy should therefore include both the chorionic gonadotropin (hCG), possible aromatase inhibitors and Selective Estrogen Receptor Modulator (SERM) preparations, such as, for example, clomiphene and tamoxifen citrate.
An interesting, rarely practiced method is taking stanozolol as part of pre-training supplementation. It is absolutely not the optimal way to consume this product, but it can be used in the case of people who are in deep reduction, who for various reasons want to use the lowest possible doses of the steroid. This allows you to improve the quality of training, especially when it comes to strictly strength parameters.
✔️ Increases the quality of muscles
✔️ Significantly increases exercise capacity.
✔️ Does not cause water retention.
✔️ Supports the regeneration of connective and bone tissue
✔️ Supports the regeneration of the nervous system.
✔️ Strongly anti-catabolic
❌ Lowers testosterone production
❌ Moderate hepatoxicity
❌ May cause hair loss, acne, aggression
❌ Increases the frequency of muscle contractions
❌ May suppress your appetite over time